The GABAA receptor is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid, the major inhibitory neurotransmitter in the central nervous system. Upon activation, the GABAA receptor selectively conducts Cl− through its pore, resulting in hyperpolarization of the neuron. This causes an inhibitory effect on neurotransmission by diminishing the chance of a successful action potential occurring. The reversal potential of the GABAA-mediated IPSP in normal solution is −70 mV, contrasting the GABAB IPSP.
The active site of the GABAA receptor is the binding site for GABA and several drugs such as muscimol, gaboxadol, and bicuculline. The protein also contains a number of different allosteric binding sites which modulate the activity of the receptor indirectly. These allosteric sites are the targets of various other drugs, including the benzodiazepines, nonbenzodiazepines, barbiturates, ethanol, neuroactive steroids, inhaled anaesthetics, and picrotoxin, among others.
GABAA receptors occur in all organisms that have a nervous system. To a limited extent the receptors can be found in non-neuronal tissues.
Zoll-Gewerkschaft fordert mehr Kontrollen gegen Sozialbetrug
Mit Blick auf eine Razzia gegen mutmaßlichen Sozialleistungsbetrug in Duisburg fordert die Deutsche Zoll- und Finanzgewerkschaft (BDZ) ein konsequenteres Vorgehen des Staates. Er wünsche sich von der zuständigen Finanzkontrolle Schwarzarbeit mehr bundesweite Schwerpunktprüfungen dieser Art, „um der Lage einigermaßen Herr zu werden“, sagte BDZ-Chef Thomas Liebel dem TV-Sender RTL. Allerdings müsse das Bundesfinanzministerium als Dienstherr des Zolls die dafür nötigen …
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